Is Sotret Isotretinoin Gel 0.05% safe to use?



Firstly I would like to say, I found your site yesterday and I’ve been hooked, reading and reading. Great job on all the information and the truly helpful answers you provide.

I read one of your articles about Sotret Isotretinoin (presuming you were talking about the tablets/capsules?) I have been using the gel(topical treatment) for spot treating for 2 years now recommended by my dermatologist and it works amazing for me. The initial acne pain is gone and if I catch a pimple in the upcoming stage it’s taken care of overnight. Larger pimples 2-3 days, reducing everyday significantly.

Now after reading your article I wondered if this too can have those side effects of the tablets, or is it safe to use?

2 Answers


Hi Ayesha, welcome to Acne Mantra!


This study shows that even excessive amounts of topical isotretinoin 0.1% (double the concentration you’re using) did not lead to significant metabolic absorption. So it is a safer option than oral isotretinoin.


So it seems safe for use. Although I’d still be careful if there was any chance of pregnancy while using this cream.


Thank you so much, it works really well for me out of all the spot treatments I’ve tried. So now I’m happy.

Your Answer

Category: Tags: asked June 13


"Skin clearing up after years, thank you!"
"No more pimples, confidence back"
"Pimples, dark spots gone, skin glows now"
"Was so depressed... Thank God found U!"
"Can face the world again, thank you"
Helpful answers, community rocks!
"Your regimen worked when nothing else did"